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Apr 06, 2014· Neutrophil NETosis is an important element of host defense as it catapults chromatin out of the cell to trap bacteria, which then are killed, , by the chromatin’s histone component. Also, during sterile inflammation TNFalpha and other mediators trigger NETosis, which elicits cytotoxic effects on host cells. The same mechanism should apply to other forms of regulated necrosis including ...

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DNA methylation is the most well studied of the epigenetic regulators in relation to environmental exposures. To date, numerous studies have detailed the manner by which DNA methylation is influenced by the environment, resulting in altered global and genespecific DNA methylation. These studies have focused on prenatal, earlylife, and adult exposure scenarios. The present review summarizes ...

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NETosis, an antimicrobial form of neutrophil cell death, is considered a primary source of citrullinated autoantigens in rheumatoid arthritis (RA) and immunogenic DNA in systemic lupus erythematosus (SLE). Activation of the citrullinating enzyme peptidylarginine deiminase type 4 (PAD4) is believed to be essential for neutrophil extracellular trap (NET) formation and NETosis.

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Derived No or Minimal Effect Level (DN(M)EL) This section provides information on the derived no or minimal effect level (DN(M)EL), the level of exposure above which a human should not be exposed to a substance. When more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole.

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